1. IDENTITY PROFILE
Markers starting with FC - These are the identity markers used to identify your cat, and to compare this cat to its sire and dam for parent verification. The 4 letters seen in this group of FC markers are abbreviations for the 4 nucleic acids that comprise DNA, and are inherited from the parents. (G, T, A, C). This group of FC markers is the unique DNA fingerprint of your cat.
ZFXY1 and ZFXY2 are markers for sex. XX (female), XY (male).
2. DISEASE PROFILE
-/- IS NEGATIVE - Your cat does not possess the physical attribute and/or disease being tested and therefore will not pass it to its offspring.
+/- IS A CARRIER - Your cat carries the physical attribute and/or disease being tested and has one normal gene and one affected gene and therefore will pass the trait to 50% of its offspring.
+/+ IS POSITIVE - Your cat carries the physical attribute and/or disease being tested and has two affected genes and therefore will pass the trait to 100% of its offspring.
If you have a carrier (+/-) at least one or both of the parents will have to be tested to determine which parent is the carrier. If one or both of the parents have been previously tested, you will automatically have the data to know which one is the carrier. This is a good reason for having all of your breeding cats tested and on file in CatDNAtest data banks.
MPS1 - Mucopolysaccharidosis (SEVERE form). The mucopolysaccharidoses (MPS)1 is a group of lysosomal storage disorders that involve the deficiency of specific enzymes required for the degradation of glycosaminoglycans. The disease is characterized by the lysosomal accumulation and urinary excretion of glycosaminoglycan dermatan sulfate . The clinical phenotype or appearance of MPS VI patients ranges from severe to relatively mild. The severe phenotype is characterized by growth retardation, coarse facial features, joint stiffness, corneal clouding, skeletal deformities, organ, and soft tissue involvement. As a result of DS storage in the heart valve and lung, the normal function of these organs is often compromised, leading to early death in affected individuals. If your MPS1 or MPS7 results show +/+ or +/-, please consult your veterinarian for complete information
MPSM - Mucopolysaccharidosis MILD form. This is the mild form of MPS1 (see above). If your MPSM results show +/+ or +/-, please consult your veterinarian for complete information.
PKD - Polycystic Kidney Disease - This disease causes kidney failure in affected animals. If your PKD results show +/+ or +/-, please consult your veterinarian for complete information.
PRA - (Progressive retinal atrophy - This is a disease that causes the retina in the back of the eye to degenerate resulting in poor vision and even blindness, please consult your veterinarian for all symptoms and complete information.
MYBPC3R - Hypertrophic Cardiomyopathy (HCM) - This is the form of HCM observed in Ragdoll cats. It causes heart failure in affected animals. If your MYBPC3R results show +/+ or +/-, please consult your veterinarian for complete information.
BLDAB - B Blood Group - This test determines the B blood type in cats. Being highly antigenic, it can be the cause of transfusion reactions, and neonatal isoerythrolysis (destruction of red blood cells) when a Type B cat is bred to a Type A cat. Type AB is very rare, but can occur. It usually does not cause reactions.
Disclaimers:
1. Unfortunately, there is evidence that this test is not validated in Ragdolls and Turkish Angora and results may differ from serologic results. Therefore please consult your veterinarian for further testing options.
2. The TX A&M lab has determined results for a sample that was genotyped for the Blood Group marker were different from genotyping results obtained from a different lab. The process has been researched further and the lab is now using two independent markers for this trait. It appears the two markers occasionally are giving different results, primarily in the case of Abyssinians and Somali. For this reason, some results for BLOOD GROUP may be reported as "inconclusive." As always when there is any question about this marker, it is recommended to further test with a serological blood test.
NOTE: The results of these tests should be used to indicate a genetic possibility of clinical disease. We recommend sharing these test results with your veterinarian. Further consultation with your own veterinarian is advised if the results indicate a positive disease marker.
3. PHYSICAL CHARACTERISTICS (COLOR PROFILE)
-/- or a/a IS NEGATIVE - Your cat does not possess the physical attribute and/or disease being tested and therefore will not pass it to its offspring.
+/- or A/a IS A CARRIER - Your cat carries the physical attribute and/or disease being tested and has one normal gene and one affected gene and therefore will pass the trait to 50% of its offspring.
+/+ or A/A IS POSITIVE - Your cat carries the physical attribute and/or disease being tested and has two affected genes and therefore will pass the trait to 100% of its offspring.
If you have a carrier (+/-) at least one or both of the parents will have to be tested to determine which parent is the carrier. If one or both of the parents have been previously tested, you will automatically have the data to know which one is the carrier. This is a good reason for having all of your breeding cats tested.
ALBIN - Albino coloration
CINNAM - Cinnamon coloration
Point1 - Siamese points
Point 2 - Burmese color shading
CHOC2 - Chocolate coloration
DILUT - Dilute coloration
This is a dilution that affects both types of melanin and results in a visual color change of black to blue, red to cream color, chocolate to lilac/lavender. This does not include dilute modifier markers.
AGOUTI - Black coloration
This mutation should be associated with a solid coat color. An a/a animal should have a solid coat color. We have been finding some cats reported as ticked having the a/a genotype though, so further investigation is necessary.(Eizirik et al. 2003)
Longhair1, Longhair2, Longhair 4, and Longhair 4_2 Longhaired cats should be +/+ at any one marker, or +/- at two markers. Note that FgF5_4 has two different markers. Due to difficulties in typing this mutation, two different markers are used. In most cases the results from these are identical. Having +/- at both Longhair4 and Longhair4_2 is not the same as being +/- at Longhair1+2, 1+4, or 2+4. There is a fourth longhair marker that we cannot test for, therefore it is possible that a longhaired animal will test negative at these three markers.
Explanation of DNA Results
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